Watch Closely (1)trofinetide will enhance the stage or result of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.ergotamine will raise the level or result of ruxolitinib topical by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.Nicotine may well provoke vasoconstriction in a few people, predisp